Article

Mutation spectrum of <i>NOD2</i> reveals recessive inheritance as a main driver of Early Onset Crohn’s Disease

2017-01-06

Abstract excerpt

Inflammatory bowel disease (IBD), clinically defined as Crohn’s disease (CD), ulcerative colitis (UC), or IBD-unclassified, results in chronic inflammation of the gastrointestinal tract in genetically susceptible hosts. Pediatric onset IBD represents ≥25% of all IBD diagnoses and often presents with intestinal stricturing, perianal disease, and failed response to conventional treatments. NOD2 was the first and is...

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Literature Corpus work: e5a71d9d-875d-5287-a7eb-9f563e57d6a7
DOI: 10.1101/098574

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