Article
Mutation spectrum of NOD2 reveals recessive inheritance as a main driver of Early Onset Crohn's Disease.
Scientific reports - 10 Mar 2021
Horowitz Julie E, Warner Neil, Staples Jeffrey, Crowley Eileen, Gosalia Nehal, Murchie Ryan, Van Hout Cristopher, Fiedler Karoline, Welch Gabriel, King Alejandra Klauer, Reid Jeffrey G, Overton John D, Baras Aris, Shuldiner Alan R, Griffiths Anne, Gottesman Omri, Muise Aleixo M, Gonzaga-Jauregui Claudia
Abstract excerpt
Inflammatory bowel disease (IBD), clinically defined as Crohn's disease (CD), ulcerative colitis (UC), or IBD-unclassified, results in chronic inflammation of the gastrointestinal tract in genetically susceptible hosts. Pediatric onset IBD represents ≥ 25% of all IBD diagnoses and often presents with intestinal stricturing, perianal disease, and failed response to conventional treatments. NOD2 was the first and...
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