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Article

NOD2 mutations predict the risk for surgery in pediatric-onset Crohn's disease.

Journal of pediatric surgery - 1 Aug 2010

Lacher Martin, Helmbrecht Johanna, Schroepf Sebastian, Koletzko Sibylle, Ballauff Antje, Classen Martin, Uhlig Holm, Hubertus Jochen, Hartl Dominik, Lohse Peter, von Schweinitz Dietrich, Kappler Roland

Abstract excerpt

BACKGROUND/PURPOSE: Three common mutations of the NOD2/CARD15 gene have been associated with Crohn disease (CD), ileal disease location, and fibrostenotic behavior. The aim of this study was to investigate the effect of these mutations on disease manifestation and the risk of surgery in a cohort of German childhood-onset CD patients. METHODS: Genotyping for the NOD2 mutations p.Arg702Trp, p.Gly908Arg, and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20713205
DOI: 10.1016/j.jpedsurg.2009.10.046

Genes

NOD2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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