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Article

Neuralized1 causes apoptosis and downregulates Notch target genes in medulloblastoma.

Neuro-oncology - 1 Dec 2010

Teider Natalia, Scott Deborah K, Neiss Adrianne, Weeraratne S Dilhan, Amani Vladimir M, Wang Yifei, Marquez Victor E, Cho Yoon-Jae, Pomeroy Scott L

Abstract excerpt

Neuralized (Neurl) is a highly conserved E3 ubiquitin ligase, which in Drosophila acts upon Notch ligands to regulate Notch pathway signaling. Human Neuralized1 (NEURL1) was investigated as a potential tumor suppressor in medulloblastoma (MB). The gene is located at 10q25.1, a region demonstrating frequent loss of heterozygosity in tumors. In addition, prior publications have shown that the Notch pathway is...

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Source

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Identifiers

PMID: 20847082
DOI: 10.1093/neuonc/noq091
PMCID: PMC3018940

Genes

NEURL1
HES1
HEY1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neuralized1 causes apoptosis and downregulates Notch target genes in medulloblastoma.PMID 20847082Read ↗

Low Expression of the NRP1 Gene Is Associated with Shorter Overall Survival in Patients with Sonic Hedgehog and Group 3 MedulloblastomaSemantic proximity Read ↗

Notch ligand Delta-like 1 as a novel molecular target in childhood neuroblastomaSemantic proximity Read ↗

Neogenin1 is a sonic hedgehog target in medulloblastoma and is necessary for cell cycle progressionSemantic proximity Read ↗

Isolation of a murine homologue of the Drosophila neuralized gene, a gene required for axonemal integrity in spermatozoa and terminal maturation of the mammary gland.Semantic proximity Read ↗

Post-translational regulation of the Numb/Notch pathway in neurogenesis and cancer by Dlk2Semantic proximity Read ↗

The NHR1 domain of Neuralized binds Delta and mediates Delta trafficking and Notch signaling.Semantic proximity Read ↗

Neuralized functions as an E3 ubiquitin ligase during Drosophila development.Semantic proximity Read ↗

NDN is an imprinted tumor suppressor gene that is downregulated in ovarian cancers through genetic and epigenetic mechanisms.Semantic proximity Read ↗

Mind bomb1 is a ubiquitin ligase essential for mouse embryonic development and Notch signaling.Semantic proximity Read ↗

REN(KCTD11) is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma.Semantic proximity Read ↗

Notch pathway activation induces neuroblastoma tumor cell growth arrestSemantic proximity Read ↗

Neuralized-2 regulates a Notch ligand in cooperation with Mind bomb-1.Semantic proximity Read ↗

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