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Article

Post-translational regulation of the Numb/Notch pathway in neurogenesis and cancer by Dlk2

2023-07-20

Abstract excerpt

Perturbations in fundamental developmental pathways have a profound influence on tumorigenesis. Numb plays a pivotal role in vertebrate development, including neurogenesis and is a key negative regulator of Notch signaling 1, 2 . Perturbation of Numb expression affects brain morphology and cell fate 3 . While extensive research has been conducted on canonical Notch ligands, regulation by vertebrate-specific non-ca...

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Literature Corpus work
795e28cc-77d4-5678-aadc-5ac4b83ecb32
DOI
10.1101/2023.07.20.549453
Open publication

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Post-translational regulation of the Numb/Notch pathway in neurogenesis and cancer by Dlk2DOI 10.1101/2023.07.20.549453
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