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Article

Mind bomb1 is a ubiquitin ligase essential for mouse embryonic development and Notch signaling.

Mechanisms of development - 1 Oct 2005

Barsi Julius C, Rajendra Rashmi, Wu Jiang I, Artzt Karen

Abstract excerpt

The Notch-Delta signaling pathway controls many conserved cell determination events. While the Notch end is fairly well characterized, the Delta end remains poorly understood. Mind bomb1 (MIB1) is one of two E3 ligases known to ubiquitinate Delta. We report here that a targeted mutation of Mib1 in mice results in embryonic lethality by E10.5. Mutants exhibit multiple defects due to their inability to modulate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16061358
DOI: 10.1016/j.mod.2005.06.005

Genes

MIB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mind bomb1 is a ubiquitin ligase essential for mouse embryonic development and Notch signaling.PMID 16061358Read ↗

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