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Article

Neogenin1 is a sonic hedgehog target in medulloblastoma and is necessary for cell cycle progression

18 Jun 2013

Abstract excerpt

The canonical Sonic Hedgehog (Shh)/Gli pathway plays multiples roles during central nervous system (CNS) development. To elucidate the molecular repertoire of Shh mediators, we have recently described novel transcriptional targets in response to Shh pathway modulation. Among them, we were able to identify Neogenin1 (Neo1), a death dependence receptor, as a new direct Shh downstream regulator in neural precursor...

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Share to Epigenetics and DNA Methylation
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PMID: 23775842
DOI: 10.1002/ijc.28330

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