Article
NDN is an imprinted tumor suppressor gene that is downregulated in ovarian cancers through genetic and epigenetic mechanisms.
Oncotarget - 19 Jan 2016
Yang Hailing, Das Partha, Yu Yinhua, Mao Weiqun, Wang Yan, Baggerly Keith, Wang Ying, Marquez Rebecca T, Bedi Anuja, Liu Jinsong, Fishman David, Lu Zhen, Bast Robert C
Abstract excerpt
NDN is a maternally imprinted gene consistently expressed in normal ovarian epithelium, is dramatically downregulated in the majority of ovarian cancers. Little or no NDN expression could be detected in 73% of 351 epithelial ovarian cancers. NDN was also downregulated in 10 ovarian cancer cell lines with total loss in 6 of 10. Re-expression of NDN decreased Bcl-2 levels and induced apoptosis, which significantly...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.