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Article

Notch pathway activation induces neuroblastoma tumor cell growth arrest

8 Jul 2011

Abstract excerpt

BACKGROUND: Notch pathway signaling has critical roles in differentiation, proliferation, and survival, and has oncogenic or tumor suppressor effects in a variety of malignancies. The goal of this study was to evaluate the effects of Notch activation on human neuroblastoma cells. PROCEDURE: Quantitative RT-PCR, immunoblots, and immunohistochemistry were used to determine the expression of Notch receptors...

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PMID: 21744479
DOI: 10.1002/pbc.23202

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