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Article

The NHR1 domain of Neuralized binds Delta and mediates Delta trafficking and Notch signaling.

Molecular biology of the cell - 1 Jan 2007

Commisso Cosimo, Boulianne Gabrielle L

Abstract excerpt

Notch signaling, which is crucial to metazoan development, requires endocytosis of Notch ligands, such as Delta and Serrate. Neuralized is a plasma membrane-associated ubiquitin ligase that is required for neural development and Delta internalization. Neuralized is comprised of three domains that include a C-terminal RING domain and two neuralized homology repeat (NHR) domains. All three domains are conserved...

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Identifiers

PMID: 17065551
DOI: 10.1091/mbc.e06-08-0753
PMCID: PMC1751308

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The NHR1 domain of Neuralized binds Delta and mediates Delta trafficking and Notch signaling.PMID 17065551Read ↗

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