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Article

REN(KCTD11) is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma.

Proceedings of the National Academy of Sciences of the United States of America - 20 Jul 2004

Di Marcotullio Lucia, Ferretti Elisabetta, De Smaele Enrico, Argenti Beatrice, Mincione Claudia, Zazzeroni Francesca, Gallo Rita, Masuelli Laura, Napolitano Maddalena, Maroder Marella, Modesti Andrea, Giangaspero Felice, Screpanti Isabella, Alesse Edoardo, Gulino Alberto

Abstract excerpt

Hedgehog signaling is suggested to be a major oncogenic pathway in medulloblastoma, which arises from aberrant development of cerebellar granule progenitors. Allelic loss of chromosome 17p has also been described as the most frequent genetic defect in this human neoplasia. This observation raises...

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Identifiers

PMID: 15249678
DOI: 10.1073/pnas.0400690101
PMCID: PMC490020

Genes

KCTD11
REN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15249678-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

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REN(KCTD11) is a suppressor of Hedgehog signaling and is deleted in human medulloblastoma.PMID 15249678Read ↗

Chromosome 17p deletion in human medulloblastoma: a missing checkpoint in the Hedgehog pathway.Semantic proximity Read ↗

Identification and Characterization of KCASH2 and KCASH3, 2 Novel Cullin3 Adaptors Suppressing Histone Deacetylase and Hedgehog Activity in MedulloblastomaSemantic proximity Read ↗

Functional loss of a noncanonical BCOR-PRC1.1 complex accelerates SHH-driven medulloblastoma formation.Semantic proximity Read ↗

Medulloblastoma tumorigenesis diverges from cerebellar granule cell differentiation in patched heterozygous mice.Semantic proximity Read ↗

Functional loss of a non-canonical BCOR-PRC1.1 complex accelerates SHH-driven medulloblastoma formationSemantic proximity Read ↗

Loss of patched and disruption of granule cell development in a pre-neoplastic stage of medulloblastoma.Semantic proximity Read ↗

Embryonic Stem Cell-Related Protein L1TD1 Is Required for Cell Viability, Neurosphere Formation, and Chemoresistance in MedulloblastomaSemantic proximity Read ↗

Neogenin1 is a sonic hedgehog target in medulloblastoma and is necessary for cell cycle progressionSemantic proximity Read ↗

Tis21 knock-out enhances the frequency of medulloblastoma in Patched1 heterozygous mice by inhibiting the Cxcl3-dependent migration of cerebellar neurons.Semantic proximity Read ↗

Expression of the neurogenic basic helix-loop-helix transcription factor NEUROG1 identifies a subgroup of medulloblastomas not expressing ATOH1.Semantic proximity Read ↗

Cdh11 acts as a tumor suppressor in a murine retinoblastoma model by facilitating tumor cell death.Semantic proximity Read ↗

A novel member of the WD-repeat gene family, WDR11, maps to the 10q26 region and is disrupted by a chromosome translocation in human glioblastoma cells.Semantic proximity Read ↗

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