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Repression of RUNX1 Activity by EVI1: A New Role of EVI1 in Leukemogenesis

15 Jun 2007

Abstract excerpt

Recurring chromosomal translocations observed in human leukemia often result in the expression of fusion proteins that are DNA-binding transcription factors. These altered proteins acquire new dimerization properties that result in the assembly of inappropriate multimeric transcription complexes that deregulate hematopoietic programs and induce leukemogenesis. Recently, we reported that the fusion protein...

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PMID: 17575132
DOI: 10.1158/0008-5472.can-06-3962

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