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Review: Aberrant <i><scp>EVI</scp>1</i> expression in acute myeloid leukaemia

5 Jan 2016

Abstract excerpt

Deregulated expression of the ecotropic virus integration site 1 (EVI1) gene is the molecular hallmark of therapy-resistant myeloid malignancies bearing chromosomal inv(3)(q21q26·2) or t(3;3)(q21;q26·2) [hereafter referred to as inv(3)/t(3;3)] abnormalities. EVI1 is a haematopoietic stemness and transcription factor with chromatin remodelling activity. Interestingly, the EVI1 gene also shows overexpression in...

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PMID: 26729571
DOI: 10.1111/bjh.13898

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Research trail→

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Review: Aberrant <i><scp>EVI</scp>1</i> expression in acute myeloid leukaemiaPMID 26729571Read ↗

Three novel cytogenetically cryptic EVI1 rearrangements associated with increased EVI1 expression and poor prognosis identified in 27 acute myeloid leukemia casesSemantic proximity Read ↗

High <i> <scp>EVI</scp> 1 </i> expression is associated with <i> <scp>MLL</scp> </i> rearrangements and predicts decreased survival in paediatric acute myeloid leukaemia: a report from the children's oncology groupSemantic proximity Read ↗

Aberrant EVI1 splicing contributes to EVI1-rearranged leukemiaSemantic proximity Read ↗

High EVI1 expression predicts outcome in younger adult patients with acute myeloid leukemia and is associated with distinct cytogenetic abnormalities.Semantic proximity Read ↗

High EVI1 levels predict adverse outcome in acute myeloid leukemia: prevalence of EVI1 overexpression and chromosome 3q26 abnormalities underestimatedSemantic proximity Read ↗

Global Identification of EVI1 Target Genes in Acute Myeloid LeukemiaSemantic proximity Read ↗

Expression of EVI1 in myelodysplastic syndromes and other hematologic malignancies without 3q26 translocationsSemantic proximity Read ↗

The retinoic acid receptor co-factor NRIP1 is uniquely upregulated and represents a therapeutic target in acute myeloid leukemia with chromosome 3q rearrangementsSemantic proximity Read ↗

High EVI1 expression predicts poor survival in acute myeloid leukemia: a study of 319 de novo AML patientsSemantic proximity Read ↗

Pathogenetic significance of ecotropic viral integration site-1 in hematological malignancies.Semantic proximity Read ↗

EVI1-rearranged acute myeloid leukemias are characterized by distinct molecular alterations.Semantic proximity Read ↗

Mutational spectrum of myeloid malignancies with inv(3)/t(3;3) reveals a predominant involvement of RAS/RTK signaling pathways.Semantic proximity Read ↗

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