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High EVI1 expression predicts poor survival in acute myeloid leukemia: a study of 319 de novo AML patients

3 Oct 2002

Abstract excerpt

The proto-oncogene EVI1 encodes a DNA binding protein and is located on chromosome 3q26. The gene is aberrantly expressed in acute myeloid leukemia (AML) patients carrying 3q26 abnormalities. Two mRNAs are transcribed from this locus: EVI1 and a fusion of EVI1 with MDS1 (MDS1-EVI1), a gene located 5' of EVI1. The purpose of this study was to investigate which of the 2 gene products is involved in transformation...

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Identifiers

PMID: 12393383
DOI: 10.1182/blood-2002-05-1459

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High EVI1 expression predicts poor survival in acute myeloid leukemia: a study of 319 de novo AML patientsPMID 12393383Read ↗

High EVI1 levels predict adverse outcome in acute myeloid leukemia: prevalence of EVI1 overexpression and chromosome 3q26 abnormalities underestimatedSemantic proximity Read ↗

High EVI1 expression predicts outcome in younger adult patients with acute myeloid leukemia and is associated with distinct cytogenetic abnormalities.Semantic proximity Read ↗

Expression and prognostic significance of different mRNA 5′‐end variants of the oncogene <i>EVI1</i> in 266 patients with de novo AML: <i>EVI1</i> and <i>MDS1/EVI1</i> overexpression both predict short remission durationSemantic proximity Read ↗

Expression of EVI1 in myelodysplastic syndromes and other hematologic malignancies without 3q26 translocationsSemantic proximity Read ↗

Intergenic splicing of MDS1 and EVI1 occurs in normal tissues as well as in myeloid leukemia and produces a new member of the PR domain family.Semantic proximity Read ↗

High EVI1 Expression Predicts Poor Outcomes in Adult Acute Myeloid Leukemia Patients with Intermediate Cytogenetic Risk Receiving ChemotherapySemantic proximity Read ↗

Three novel cytogenetically cryptic EVI1 rearrangements associated with increased EVI1 expression and poor prognosis identified in 27 acute myeloid leukemia casesSemantic proximity Read ↗

Down-regulation of EVI1 is associated with epigenetic alterations and good prognosis in patients with acute myeloid leukemiaSemantic proximity Read ↗

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Review: Aberrant <i><scp>EVI</scp>1</i> expression in acute myeloid leukaemiaSemantic proximity Read ↗

High <i> <scp>EVI</scp> 1 </i> expression is associated with <i> <scp>MLL</scp> </i> rearrangements and predicts decreased survival in paediatric acute myeloid leukaemia: a report from the children's oncology groupSemantic proximity Read ↗

Activation of EVI1 gene expression in human acute myelogenous leukemias by translocations spanning 300-400 kilobases on chromosome band 3q26.Semantic proximity Read ↗

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