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Article

Nuclear retention of unspliced pre-mRNAs by mutant DHX16/hPRP2, a spliceosomal DEAH-box protein.

The Journal of biological chemistry - 12 Nov 2010

Gencheva Marieta, Lin Ting-Yu, Wu Xiwei, Yang Lixin, Richard Caroline, Jones Matthew, Lin Shwu-Bin, Lin Ren-Jang

Abstract excerpt

Defective or imbalanced expression of spliceosomal factors has been linked to human disease; however, how a defective spliceosome affects intron-containing gene transcripts in human cells is largely unknown. DEAH-box protein DHX16 is a human orthologue of Saccharomyces cerevisiae spliceosomal protein Prp2, an RNA-dependent ATPase that activates the spliceosome before the first catalytic step of splicing. Yeast...

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Identifiers

PMID: 20841358
DOI: 10.1074/jbc.M110.122309
PMCID: PMC2975187

Genes

DHX16

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Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Nuclear retention of unspliced pre-mRNAs by mutant DHX16/hPRP2, a spliceosomal DEAH-box protein.PMID 20841358Read ↗

The DEAH-box splicing factor Prp16 unwinds RNA duplexes in vitro.Semantic proximity Read ↗

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