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Article

The DEAH-box splicing factor Prp16 unwinds RNA duplexes in vitro.

Current biology : CB - 9 Apr 1998

Wang Y, Wagner J D, Guthrie C

Abstract excerpt

BACKGROUND: During pre-mRNA splicing, dynamic rearrangement of RNA secondary structure within the spliceosome is crucial for intron recognition and formation of the catalytic core. Splicing factors belonging to the DExD/DExH-box family of RNA-dependent ATPases are thought to have a central role in directing these rearrangements by unwinding RNA helices. Proof of this hypothesis has, however, been conspicuously...

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PMID: 9550699
DOI: 10.1016/s0960-9822(98)70178-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The DEAH-box splicing factor Prp16 unwinds RNA duplexes in vitro.PMID 9550699Read ↗

Genetic interactions between the yeast RNA helicase homolog Prp16 and spliceosomal snRNAs identify candidate ligands for the Prp16 RNA-dependent ATPase.Semantic proximity Read ↗

Plasmodium falciparum Prp16 homologue and its role in splicing.Semantic proximity Read ↗

The DEAH-box protein PRP22 is an ATPase that mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes.Semantic proximity Read ↗

A mechanism to enhance mRNA splicing fidelity: the RNA-dependent ATPase Prp16 governs usage of a discard pathway for aberrant lariat intermediates.Semantic proximity Read ↗

A dominant negative mutation in a spliceosomal ATPase affects ATP hydrolysis but not binding to the spliceosome.Semantic proximity Read ↗

A putative ATP binding protein influences the fidelity of branchpoint recognition in yeast splicing.Semantic proximity Read ↗

Opposing classes of prp8 alleles modulate the transition between the catalytic steps of pre-mRNA splicing.Semantic proximity Read ↗

Evidence that U2/U6 helix I promotes both catalytic steps of pre-mRNA splicing and rearranges in between these steps.Semantic proximity Read ↗

Brr2p carboxy-terminal Sec63 domain modulates Prp16 splicing RNA helicase.Semantic proximity Read ↗

Characterization of Cwc2, U6 snRNA, and Prp8 interactions destabilized by Prp16 ATPase at the transition between the first and second steps of splicing.Semantic proximity Read ↗

Nuclear retention of unspliced pre-mRNAs by mutant DHX16/hPRP2, a spliceosomal DEAH-box protein.Semantic proximity Read ↗

Remodeling of U2-U6 snRNA helix I during pre-mRNA splicing by Prp16 and the NineTeen Complex protein Cwc2.Semantic proximity Read ↗

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