Article
A novel angiotensin I-converting enzyme mutation (S333W) impairs N-domain enzymatic cleavage of the anti-fibrotic peptide, AcSDKP.
PloS one - 1 Jan 2014
Danilov Sergei M, Wade Michael S, Schwager Sylva L, Douglas Ross G, Nesterovitch Andrew B, Popova Isolda A, Hogarth Kyle D, Bhardwaj Nakul, Schwartz David E, Sturrock Edward D, Garcia Joe G N
Abstract excerpt
BACKGROUND: Angiotensin I-converting enzyme (ACE) has two functional N- and C-domain active centers that display differences in the metabolism of biologically-active peptides including the hemoregulatory tetrapeptide, Ac-SDKP, hydrolysed preferentially by the N domain active center. Elevated Ac-SDKP concentrations are associated with reduced tissue fibrosis. RESULTS: We identified a patient of African descent...
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