Article
Glycosylation of active human renin is necessary for secretion: effect of targeted modifications of Asn-5 and Asn-75.
DNA and cell biology - 1 May 1993
Rothwell V, Kosowski S, Hadjilambris O, Baska R, Norman J
Abstract excerpt
Renin is a mammalian aspartic protease that is rate-limiting in the renin-angiotensin cascade. Preprorenin is the translational product of the human renin gene and is secreted as prorenin, an inactive zymogen, primarily from the juxtaglomerular cells of the kidney. It has previously been shown th...
Topics
- Animals
- Asparagine
- Baculoviridae
- Base Sequence
- CHO Cells
- Cells, Cultured
- Cloning, Molecular
- Cricetinae
- DNA
- Enzyme Precursors
- Glycosylation
- Humans
- Molecular Sequence Data
- Moths
- Mutagenesis, Site-Directed
- Mutation
- Renin