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Article

Glycosylation of active human renin is necessary for secretion: effect of targeted modifications of Asn-5 and Asn-75.

DNA and cell biology - 1 May 1993

Rothwell V, Kosowski S, Hadjilambris O, Baska R, Norman J

Abstract excerpt

Renin is a mammalian aspartic protease that is rate-limiting in the renin-angiotensin cascade. Preprorenin is the translational product of the human renin gene and is secreted as prorenin, an inactive zymogen, primarily from the juxtaglomerular cells of the kidney. It has previously been shown that the 46-amino-acid pro domain is not necessary for the secretion of fully active or mature renin from mammalian...

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Identifiers

PMID: 8494607
DOI: 10.1089/dna.1993.12.291

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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