Article
Site-specific O-Glycosylation by Polypeptide N-Acetylgalactosaminyltransferase 2 (GalNAc-transferase T2) Co-regulates β1-Adrenergic Receptor N-terminal Cleavage.
The Journal of biological chemistry - 17 Mar 2017
Goth Christoffer K, Tuhkanen Hanna E, Khan Hamayun, Lackman Jarkko J, Wang Shengjun, Narimatsu Yoshiki, Hansen Lasse H, Overall Christopher M, Clausen Henrik, Schjoldager Katrine T, Petäjä-Repo Ulla E
Abstract excerpt
The β1-adrenergic receptor (β1AR) is a G protein-coupled receptor (GPCR) and the predominant adrenergic receptor subtype in the heart, where it mediates cardiac contractility and the force of contraction. Although it is the most important target for β-adrenergic antagonists, such as β-blockers, relatively little is yet known about its regulation. We have shown previously that β1AR undergoes constitutive and...
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