The structural role of N-linked glycans on human glypican-1.

doi:10.1021/bi200218s

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Article

The structural role of N-linked glycans on human glypican-1.

Biochemistry - 1 Nov 2011

Svensson Gabriel, Hyrenius Wittsten Axel, Linse Sara, Mani Katrin

Abstract excerpt

Glypicans are cell-surface heparan sulfate proteoglycans that regulate developmental signaling pathways by binding growth factors to their heparan sulfate chains. The primary structures of glypican core proteins contain potential N-glycosylation sites, but the importance of N-glycosylation in glypicans has never been investigated in detail. Here, we studied the role of the possible N-glycosylation sites at Asn-79...

Topics

Cell Line
Glycosylation
Glypicans
Humans
Mutation
Polysaccharides
Protein Biosynthesis
Protein Folding
Protein Stability
Recombinant Proteins

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Open in PubMed

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PMID: 21932778
DOI: 10.1021/bi200218s

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