Article
Stat3 dimerization regulated by reversible acetylation of a single lysine residue.
Science (New York, N.Y.) - 14 Jan 2005
Yuan Zheng-Long, Guan Ying-Jie, Chatterjee Devasis, Chin Y Eugene
Abstract excerpt
Upon cytokine treatment, members of the signal transducers and activators of transcription (STAT) family of proteins are phosphorylated on tyrosine and serine sites within the carboxyl-terminal region in cells. We show that in response to cytokine treatment, Stat3 is also acetylated on a single lysine residue, Lys685. Histone acetyltransferase p300-mediated Stat3 acetylation on Lys685 was reversible by type I...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.