Separating the anti-apoptotic and mitotic roles of survivin.

Abstract excerpt

Survivin is a bifunctional protein that acts as a suppressor of apoptosis and has an essential role in mitosis. To date whether these two functions can be divorced has not been addressed. Here we show that the linker region between the BIR (baculovirus inhibitor of apoptosis repeat) domain of survivin and COOH-terminal alpha helix may be the key to separating its roles. When overexpressed survivin is present in...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Apoptosis
• Share to Cell Line, Tumor
• Share to Inhibitor of Apoptosis Proteins