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Survivin: A molecular biomarker in cancer.

The Indian journal of medical research - 1 Apr 2015

Jaiswal Praveen Kumar, Goel Apul, Mittal R D

Abstract excerpt

Survivin, a member of the inhibitor of apoptosis (IAP) protein family that inhibits caspases and blocks cell death, is highly expressed in most cancers and is associated with a poor clinical outcome. Survivin has consistently been identified by molecular profiling analysis to be associated with high tumour grade cancers, different disease survival and recurrence. Polymorphisms in the survivin gene are emerging as...

Topics

Apoptosis
Biomarkers, Tumor
Gene Expression Regulation, Neoplastic
Humans
Inhibitor of Apoptosis Proteins
Molecular Targeted Therapy
Neoplasms
Polymorphism, Single Nucleotide
Survivin

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26112839
DOI: 10.4103/0971-5916.159250
PMCID: PMC4510718

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