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Article

The Transcriptional Regulator Sin3A Contributes to the Oncogenic Potential of STAT3

28 Jan 2019

Abstract excerpt

Abstract Epigenetic silencing of promoter and enhancer regions is a common phenomenon in malignant cells. The transcription factor STAT3 is aberrantly activated in several tumors, where its constitutive acetylation accounts for the transcriptional repression of a number of tumor suppressor genes (TSG) via molecular mechanisms that remain to be understood. Using nucleophosmin-anaplastic lymphoma kinase–positive...

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PMID: 30692217
DOI: 10.1158/0008-5472.can-18-0359

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