Variation in GNB3 predicts response and adverse reactions to antidepressants.

doi:10.1177/0269881110376683

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Article

Variation in GNB3 predicts response and adverse reactions to antidepressants.

Journal of psychopharmacology (Oxford, England) - 1 Jul 2011

Keers Robert, Bonvicini Cristian, Scassellati Catia, Uher Rudolf, Placentino Anna, Giovannini Caterina, Rietschel Marcella, Henigsberg Neven, Kozel Dejan, Mors Ole, Maier Wolfgang, Hauser Joanna, Souery Daniel, Mendlewicz Julien, Schmäl Christine, Zobel Astrid, Larsen Erik R, Szczepankiewicz Aleksandra, Kovacic Zrnka, Elkin Amanda, Craig Ian, McGuffin Peter, Farmer Anne E, Aitchison Katherine J, Gennarelli Massimo

Abstract excerpt

There is substantial inter-individual variation in response and adverse reactions to antidepressants, and genetic variation may, in part, explain these differences. GNB3 encodes the β3 subunit of the G protein complex, which is involved in the downstream signalling cascade following monoamine receptor activation. A functional polymorphism in this gene (C825T) has been associated with response to antidepressants....

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Identifiers

PMID: 20826553
DOI: 10.1177/0269881110376683

Genes

GNB3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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