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Article

Antidepressant response and intolerance to SSRI is not influenced by G-protein beta3 subunit gene C825T polymorphism in Japanese major depressive patients.

Progress in neuro-psychopharmacology & biological psychiatry - 15 May 2008

Kato Masaki, Wakeno Masataka, Okugawa Gaku, Fukuda Tsuyoshi, Takekita Yoshiteru, Hosoi Yuka, Azuma Junichi, Kinoshita Toshihiko, Serretti Alessandro

Abstract excerpt

The G-protein beta3 subunit (GNB3) gene is a key modulator of signal transduction and is a major candidate for SSRIs response. The aim of the present study is to test a possible effect of the C825T polymorphism on the antidepressant response and intolerance to selective serotonin reuptake inhibitors (SSRIs) in 146 Japanese samples with major depression treated with paroxetine or fluvoxamine for 6 weeks. The...

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Identifiers

PMID: 18325652
DOI: 10.1016/j.pnpbp.2008.01.019

Genes

GNB3

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Antidepressant response and intolerance to SSRI is not influenced by G-protein beta3 subunit gene C825T polymorphism in Japanese major depressive patients.PMID 18325652Read ↗

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