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Article

The GNB3 C825T polymorphism as a pharmacogenetic marker in the treatment of hypertension, obesity, and depression.

Pharmacogenetics and genomics - 1 Sept 2011

Klenke Stefanie, Kussmann Martin, Siffert Winfried

Abstract excerpt

Heterotrimeric guanine-binding proteins (G proteins) transmit signals from the cell surface to intracellular signal cascades. The β3-subunit encoded by the gene GNB3 is widely expressed and, therefore, involved in various physiological and pathophysiological processes. A C825T polymorphism located in exon 10 of GNB3 was described in 1998 and the T allele was associated with alternative splicing and with increased...

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Identifiers

PMID: 21709600
DOI: 10.1097/FPC.0b013e3283491153

Genes

GNB3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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