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Article

Notch signaling contributes to proliferation and tumor formation of human T-cell leukemia virus type 1-associated adult T-cell leukemia.

Proceedings of the National Academy of Sciences of the United States of America - 21 Sept 2010

Pancewicz Joanna, Taylor John M, Datta Abhik, Baydoun Hicham H, Waldmann Thomas A, Hermine Olivier, Nicot Christophe

Abstract excerpt

The Notch signaling pathway plays an important role in cellular proliferation, differentiation, and apoptosis. Unregulated activation of Notch signaling can result in excessive cellular proliferation and cancer. Human T-cell leukemia virus type 1 (HTLV-I) is the etiological agent of adult T-cell leukemia (ATL). The disease has a dismal prognosis and is invariably fatal. In this study, we report a high frequency...

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Identifiers

PMID: 20823234
DOI: 10.1073/pnas.1010722107
PMCID: PMC2944748

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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