Article
Notch signaling in T-cell acute lymphoblastic leukemia.
Future oncology (London, England) - 1 Aug 2005
Weng Andrew P, Lau Arthur
Abstract excerpt
T-cell acute lymphoblastic leukemia (T-ALL) is a form of pediatric leukemia that is thought to be caused by approximately 12 distinct chromosomal translocations that lead to aberrant expression of as many different cellular genes. Development of novel, rational therapies against such a diverse set of mechanistic targets has thus been a formidable challenge. Recent studies, however, have identified a large...
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