Article
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia.
Science (New York, N.Y.) - 8 Oct 2004
Weng Andrew P, Ferrando Adolfo A, Lee Woojoong, Morris John P, Silverman Lewis B, Sanchez-Irizarry Cheryll, Blacklow Stephen C, Look A Thomas, Aster Jon C
Abstract excerpt
Very rare cases of human T cell acute lymphoblastic leukemia (T-ALL) harbor chromosomal translocations that involve NOTCH1, a gene encoding a transmembrane receptor that regulates normal T cell development. Here, we report that more than 50% of human T-ALLs, including tumors from all major molecular oncogenic subtypes, have activating mutations that involve the extracellular heterodimerization domain and/or the...
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