Article
Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia.
Nature medicine - 1 Jan 2007
Vilimas Tomas, Mascarenhas Joaquina, Palomero Teresa, Mandal Malay, Buonamici Silvia, Meng Fanyong, Thompson Benjamín, Spaulding Christina, Macaroun Sami, Alegre Maria-Luisa, Kee Barbara L, Ferrando Adolfo, Miele Lucio, Aifantis Iannis
Abstract excerpt
T-cell acute lymphoblastic leukemia (T-ALL), unlike other ALL types, is only infrequently associated with chromosomal aberrations, but it was recently shown that most individuals with T-ALL carry activating mutations in the NOTCH1 gene. However, the signaling pathways and target genes responsible for Notch1-induced neoplastic transformation remain undefined. We report here that constitutively active Notch1...
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