Article
Nonpolar inactivation of the hypervariable streptococcal inhibitor of complement gene (sic) in serotype M1 Streptococcus pyogenes significantly decreases mouse mucosal colonization.
Infection and immunity - 1 Feb 2000
Lukomski S, Hoe N P, Abdi I, Rurangirwa J, Kordari P, Liu M, Dou S J, Adams G G, Musser J M
Abstract excerpt
Group A Streptococcus (GAS) is a human pathogen that commonly infects the upper respiratory tract. GAS serotype M1 strains are frequently isolated from human infections and contain the gene encoding the hypervariable streptococcal inhibitor of complement protein (Sic). It was recently shown that Sic variants were rapidly selected on mucosal surfaces in epidemic waves caused by M1 strains, an observation...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.