Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Intrahost sequence variation in the streptococcal inhibitor of complement gene in patients with human pharyngitis.

The Journal of infectious diseases - 15 Feb 2003

Matsumoto Masakado, Hoe Nancy P, Liu Mengyao, Beres Stephen B, Sylva Gail L, Brandt Claudia M, Haase Gerhard, Musser James M

Abstract excerpt

Selection of new variants of the streptococcal inhibitor of complement protein has been implicated in the perpetuation of epidemics caused by serotype M1 strains of group A Streptococcus (GAS). The frequency at which new streptococcal inhibitor of complement (Sic) variants arise in an infected individual is not known. To study this issue, the sic gene was sequenced in 100 isolates cultured from throat swabs of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Disease
Share to Cloning, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Collagen

Share to Gene Deletion

Share to Pharyngitis

Share to Pharynx

Share to Streptococcal Infections

Share to Streptococcus pyogenes

Source

Identifiers

PMID: 12599077
DOI: 10.1086/367993

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Intrahost sequence variation in the streptococcal inhibitor of complement gene in patients with human pharyngitis.PMID 12599077Read ↗

Distribution of streptococcal inhibitor of complement variants in pharyngitis and invasive isolates in an epidemic of serotype M1 group A Streptococcus infection.Semantic proximity Read ↗

Hypervariability generated by natural selection in an extracellular complement-inhibiting protein of serotype M1 strains of group A Streptococcus.Semantic proximity Read ↗

Streptococcal inhibitor of complement promotes innate immune resistance phenotypes of invasive M1T1 group A Streptococcus.Semantic proximity Read ↗

Characterization of group A Streptococcus strains recovered from Mexican children with pharyngitis by automated DNA sequencing of virulence-related genes: unexpectedly large variation in the gene (sic) encoding a complement-inhibiting protein.Semantic proximity Read ↗

Variation in sic gene encoding complement-inhibiting protein of Streptococcus pyogenes serotype M1 isolates in Japan.Semantic proximity Read ↗

Molecular characterization of an invasive phenotype of group A Streptococcus arising during human infection using whole genome sequencing of multiple isolates from the same patient.Semantic proximity Read ↗

Sequence diversity of sicG among group C and G Streptococcus dysgalactiae subspecies equisimilis isolates associated with human infections in western Norway.Semantic proximity Read ↗

Insight into the molecular basis of pathogen abundance: Group A Streptococcus inhibitor of complement inhibits bacterial adherence and internalization into human cellsSemantic proximity Read ↗

Nonpolar inactivation of the hypervariable streptococcal inhibitor of complement gene (sic) in serotype M1 Streptococcus pyogenes significantly decreases mouse mucosal colonization.Semantic proximity Read ↗

SIC, a secreted protein of Streptococcus pyogenes that inactivates antibacterial peptides.Semantic proximity Read ↗

Protein SIC, a Novel Extracellular Protein of Streptococcus pyogenes Interfering with Complement FunctionSemantic proximity Read ↗

Rapid Molecular Genetic Subtyping of Serotype M1 Group A <i>Streptococcus</i> StrainsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.