Article
Distribution of streptococcal inhibitor of complement variants in pharyngitis and invasive isolates in an epidemic of serotype M1 group A Streptococcus infection.
The Journal of infectious diseases - 15 Feb 2001
Hoe N P, Vuopio-Varkila J, Vaara M, Grigsby D, De Lorenzo D, Fu Y X, Dou S J, Pan X, Nakashima K, Musser J M
Abstract excerpt
Streptococcal inhibitor of complement (Sic) is a highly polymorphic extracellular protein made predominantly by serotype M1 group A Streptococcus (GAS). New variants of the Sic protein frequently appear in M1 epidemics as a result of positive natural selection. To gain further understanding of the molecular basis of M1 epidemics, the sic gene was sequenced from 471 pharyngitis and 127 pyogenic and blood isolates...
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