Article

Vaccine-induced, but not natural immunity, against the Streptococcal Inhibitor of Complement protects against invasive disease

2020-11-23

Abstract excerpt

Highly pathogenic emm1 Streptococcus pyogenes strains secrete the multidomain Streptococcal inhibitor of complement (SIC) that binds and inactivates components of the innate immune response. We aimed to determine if naturally occurring or vaccine-induced antibodies to SIC are protective against invasive S. pyogenes infection. Immunisation with full length SIC protected mice against systemic bacterial disseminati...

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Literature Corpus work: 28ff5d4a-c5d6-5141-bf0c-aac4bdc40289
DOI: 10.1101/2020.11.22.393389

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