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Article

SIC, a secreted protein of Streptococcus pyogenes that inactivates antibacterial peptides.

The Journal of biological chemistry - 9 May 2003

Frick Inga-Maria, Akesson Per, Rasmussen Magnus, Schmidtchen Artur, Björck Lars

Abstract excerpt

Some isolates of the significant human pathogen Streptococcus pyogenes, including virulent strains of the M1 serotype, secrete protein SIC. This molecule, secreted in large quantities, interferes with complement function. As a result of natural selection, SIC shows a high degree of variation. Here we provide a plausible explanation for this variation and the fact that strains of the M1 serotype are the most...

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Identifiers

PMID: 12621031
DOI: 10.1074/jbc.M301995200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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