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Article

Power and sample size calculations for Mendelian randomization studies using one genetic instrument.

International journal of epidemiology - 1 Aug 2013

Freeman Guy, Cowling Benjamin J, Schooling C Mary

Abstract excerpt

Mendelian randomization, which is instrumental variable analysis using genetic variants as instruments, is an increasingly popular method of making causal inferences from observational studies. In order to design efficient Mendelian randomization studies, it is essential to calculate the sample sizes required. We present formulas for calculating the power of a Mendelian randomization study using one genetic...

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PMID: 23934314
DOI: 10.1093/ije/dyt110

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