Article
A calmodulin/inositol 1,4,5-trisphosphate (IP3) receptor-binding region targets TRPC3 to the plasma membrane in a calmodulin/IP3 receptor-independent process.
The Journal of biological chemistry - 11 Jul 2003
Wedel Barbara J, Vazquez Guillermo, McKay Richard R, St J Bird Gary, Putney James W
Abstract excerpt
Conformational coupling with the inositol 1,4,5-trisphosphate (IP3) receptor has been suggested as a possible mechanism of activation of TRPC3 channels and a region in the C terminus of TRPC3 has been shown to interact with the IP3 receptor as well as calmodulin (calmodulin/IP3 receptor-binding (...
Topics
- Amino Acid Sequence
- Animals
- Calcium
- Calcium Channels
- Calmodulin
- Carbachol
- Cell Line
- Chickens
- Cholinergic Agonists
- Conserved Sequence
- Diglycerides
- Flow Cytometry
- Gene Deletion
- Humans
- Inositol 1,4,5-Trisphosphate Receptors
- Ion Channels
- Kinetics
- Microscopy, Confocal