Article
Sex-dependent behavioral effects of Mthfr deficiency and neonatal GABA potentiation in mice.
Behavioural brain research - 20 Jan 2011
Levav-Rabkin Tamar, Blumkin Elinor, Galron Dalia, Golan Hava M
Abstract excerpt
The methylenetetrahydrofolate reductase (Mthfr) gene and/or abnormal homocysteine-folate metabolism are associated with increased risk for birth defects and neuropsychiatric diseases. In addition, disturbances of the GABAergic system in the brain as well as Mthfr polymorphism are associated with neurodevelopmental disorders such as schizophrenia and autism. In the present study we performed behavioral phenotyping...
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