Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Folate intake, MTHFR genotype, and sex modulate choline metabolism in mice.

The Journal of nutrition - 1 Aug 2011

Chew Tina W, Jiang Xinyin, Yan Jian, Wang Wei, Lusa Amanda L, Carrier Bradley J, West Allyson A, Malysheva Olga V, Brenna J Thomas, Gregory Jesse F, Caudill Marie A

Abstract excerpt

Choline and folate are interrelated in 1-carbon metabolism, mostly because of their shared function as methyl donors for homocysteine remethylation. Folate deficiency and mutations of methylenetetrahydrofolate reductase (MTHFR) reduce the availability of a major methyl donor, 5-methyltetrahydrofolate, which in turn may lead to compensatory changes in choline metabolism. This study investigated the hypothesis that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Choline
Share to Folic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Mice, Knockout

Share to Reverse Transcriptase Polymerase Chain Reaction

Share to Sex Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 21697299
DOI: 10.3945/jn.111.138859
PMCID: PMC3138639

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Folate intake, MTHFR genotype, and sex modulate choline metabolism in mice.PMID 21697299Read ↗

Mild Choline Deficiency and MTHFD1 Synthetase Deficiency Interact to Increase Incidence of Developmental Delays and Defects in Mice.Semantic proximity Read ↗

Folate Deficiency and/or the Genetic Variant Mthfr677C >T Can Drive Hepatic Fibrosis or Steatosis in Mice, in a Sex-Specific Manner.Semantic proximity Read ↗

Genetic impairments in folate enzymes increase dependence on dietary choline for phosphatidylcholine production at the expense of betaine synthesis.Semantic proximity Read ↗

MTHFR C677T genotype influences the isotopic enrichment of one-carbon metabolites in folate-compromised men consuming d9-choline.Semantic proximity Read ↗

Choline metabolitesSemantic proximity Read ↗

Dietary choline deficiency causes DNA strand breaks and alters epigenetic marks on DNA and histones.Semantic proximity Read ↗

Nutritional genomics: defining the dietary requirement and effects of choline.Semantic proximity Read ↗

Dietary methionine/choline deficiency affects behavioural and molecular circadian rhythmsSemantic proximity Read ↗

High folic acid consumption leads to pseudo-MTHFR deficiency, altered lipid metabolism, and liver injury in mice.Semantic proximity Read ↗

Folate intake and the MTHFR C677T genotype influence choline status in young Mexican American women.Semantic proximity Read ↗

Dietary and genetic manipulations of folate metabolism differentially affect neocortical functions in mice.Semantic proximity Read ↗

Common Genetic Variants Alter Metabolism and Influence Dietary Choline Requirements.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.