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Article

Gender-specific effect of Mthfr genotype and neonatal vigabatrin interaction on synaptic proteins in mouse cortex.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Jul 2011

Blumkin Elinor, Levav-Rabkin Tamar, Melamed Osnat, Galron Dalia, Golan Hava M

Abstract excerpt

The enzyme methylenetetrahydrofolate reductase (MTHFR) is a part of the homocysteine and folate metabolic pathways, affecting the methylations of DNA, RNA, and proteins. Mthfr deficiency was reported as a risk factor for neurodevelopmental disorders such as autism spectrum disorder and schizophrenia. Neonatal disruption of the GABAergic system is also associated with behavioral outcomes. The interaction between...

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Source

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Identifiers

PMID: 21490592
DOI: 10.1038/npp.2011.52
PMCID: PMC3138666

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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