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Article

Glutamatergic synapse protein composition of wild-type mice is sensitive to in utero MTHFR genotype and the timing of neonatal vigabatrin exposure.

European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Oct 2015

Zuckerman Chava, Blumkin Elinor, Melamed Osnat, Golan Hava M

Abstract excerpt

The enzyme methylenetetrahydrofolate-reductase (MTHFR) is part of the homocysteine and folate metabolic pathways. In utero, Mthfr-deficient environment has been reported as a risk factor for neurodevelopmental disorders such as autism and neural tube defects. Neonatal disruption of the GABAergic system is also associated with behavioral outcomes. The interaction between Mthfr deficiency and neonatal exposure to...

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Source

Identifiers

PMID: 26235956
DOI: 10.1016/j.euroneuro.2015.06.004

Genes

MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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