Article
Influence of methylenetetrahydrofolate 677C > T variant in murine models following valproic acid exposure.
Reproductive toxicology (Elmsford, N.Y.) - 1 Oct 2025
Yang Man, Li Yinchao, Lei Lei, Zou Shangnan, Lai Huanling, Xing Yue, Fang Yubao, Zou Qihang, Zhang Yaqian, Yang Xiaofeng, Zhou Liemin
Abstract excerpt
The teratogenic effects of valproic acid (VPA) can lead to abnormal fetal development, which may be related to abnormal maternal one-carbon metabolism. Methylene-tetrahydrofolate reductase (MTHFR) is a key enzyme involved in one-carbon metabolism. Variations in MTHFR, particularly 677 C>T, are associated with susceptibility to teratogenicity. However, the current research is limited to clinical practice....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.