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Article

Inactivation of the maternal fragile X gene results in sensitization of GABAB receptor function in the offspring.

The Journal of pharmacology and experimental therapeutics - 1 Dec 2008

Zupan Bojana, Toth Miklos

Abstract excerpt

Fragile X syndrome is an X-linked disorder caused by the inactivation of the FMR1 gene, with symptoms ranging from impaired cognitive functions to seizures, anxiety, sensory abnormalities, and hyperactivity. Although fragile X syndrome is considered a typical Mendelian disorder, we have recently reported that the environment, specifically the fmr1(+/-) or fmr1(-/-) [H or knockout (KO)] maternal environment,...

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Share to Fragile X Mental Retardation Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Knockout

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Share to Receptors, GABA-B

Source

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Identifiers

PMID: 18812493
DOI: 10.1124/jpet.108.143990
PMCID: PMC2666962

Genes

FMR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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