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Article

Behavioral phenotyping of glutathione-deficient mice: relevance to schizophrenia and bipolar disorder.

Behavioural brain research - 15 Jan 2012

Kulak Anita, Cuenod Michel, Do Kim Q

Abstract excerpt

Redox-dysregulation represents a common pathogenic mechanism in schizophrenia (SZ) and bipolar disorder (BP). It may in part arise from a genetically compromised synthesis of glutathione (GSH), the major cellular antioxidant and redox-regulator. Allelic variants of the genes coding for the rate-limiting GSH synthesizing enzyme glutamate-cysteine-ligase modifier (GCLM) and/or catalytic (GCLC) subunit have been...

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Source

Identifiers

PMID: 22033334
DOI: 10.1016/j.bbr.2011.10.020

Genes

GCLM
GCLC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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