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Article

Betaine rescue of an animal model with methylenetetrahydrofolate reductase deficiency.

The Biochemical journal - 15 Sept 2004

Schwahn Bernd C, Laryea Maurice D, Chen Zhoutao, Melnyk Stepan, Pogribny Igor, Garrow Timothy, James S Jill, Rozen Rima

Abstract excerpt

MTHFR (methylenetetrahydrofolate reductase) catalyses the synthesis of 5-methyltetrahydrofolate, the folate derivative utilized in homocysteine remethylation to methionine. A severe deficiency of MTHFR results in hyperhomocysteinaemia and homocystinuria. Betaine supplementation has proven effecti...

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Source

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Identifiers

PMID: 15217352
DOI: 10.1042/BJ20040822
PMCID: PMC1133958

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15217352-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Betaine rescue of an animal model with methylenetetrahydrofolate reductase deficiency.PMID 15217352Read ↗

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