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Article

Dietary and genetic manipulations of folate metabolism differentially affect neocortical functions in mice.

Neurotoxicology and teratology - 1 Jan 2000

Ash J A, Jiang X, Malysheva O V, Fiorenza C G, Bisogni A J, Levitsky D A, Strawderman M S, Caudill M A, Stover P J, Strupp B J

Abstract excerpt

Converging evidence suggests that folate-mediated one-carbon metabolism may modulate cognitive functioning throughout the lifespan, but few studies have directly tested this hypothesis. This study examined the separate and combined effects of dietary and genetic manipulations of folate metabolism on neocortical functions in mice, modeling a common genetic variant in the MTHFD1 gene in humans. Mutant...

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Source

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Identifiers

PMID: 23684804
DOI: 10.1016/j.ntt.2013.05.002
PMCID: PMC5096640

Genes

MTHFD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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