Article
The L55M polymorphism of paraoxonase-1 is a risk factor for rheumatoid arthritis.
Genetics and molecular research : GMR - 31 Aug 2010
Hashemi M, Moazeni-Roodi A K, Fazaeli A, Sandoughi M, Taheri M, Bardestani G R, Zakeri Z, Kordi-Tamandani D M, Ghavami S
Abstract excerpt
Paraoxonase-1 (PON1) is a high-density lipoprotein-associated enzyme that exhibits antioxidant and antiatherogenic activities. We examined a possible association between T172A (L55M) and T(-107)C polymorphisms and rheumatoid arthritis. These polymorphisms were determined in 88 rheumatoid arthritis patients and 78 healthy subjects, using the tetra-amplification refractory mutation system-PCR method. The prevalence...
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