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Article

The Role of NRAMP1/SLC11A1 Gene Variant D543N (1730G/A) in the Genetic Susceptibility to Develop Rheumatoid Arthritis in the Mexican Mestizo population.

Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion - 1 Jan 2000

Niño-Moreno Perla, Turrubiartes-Martínez Edgar, Oceguera-Maldonado Brenda, Baltazar-Benítez Nubia, Negrete-González Cindy, Oliva-Ramírez Brenda, Baranda Lourdes, González-Amaro Roberto

Abstract excerpt

BACKGROUND: Rheumatoid arthritis is a chronic inflammatory disease whose cause has not been fully elucidated. However, genetic factors seem to have an important role in its pathogenesis. OBJECTIVE: We analyzed the possible association between rheumatoid arthritis and variants of the SLC11A1 gene, which encodes for NRAMP1, a protein involved in the activation of phagocytes and synthesis of proinflammatory...

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PMID: 28239176
DOI: 10.24875/ric.17002152

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