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PON-1 haplotype (-108C>T, L55M, and Q192R) modulates the serum levels and activity PONase promoting an atherogenic lipid profile in rheumatoid arthritis patients.

Clinical rheumatology - 1 Feb 2021

Zaragoza-García Oscar, Guzmán-Guzmán Iris Paola, Moreno-Godínez Ma Elena, Navarro-Zarza José Eduardo, Antonio-Vejar Verónica, Ramírez Mónica, Parra-Rojas Isela

Abstract excerpt

INTRODUCTION/OBJECTIVE: Paraoxonase 1 (PON1) promotes antioxidant and antiatherogenic activity related to the hydrolysis of oxidized lipids of low-density lipoproteins. In rheumatoid arthritis (RA) patients, it has been reported that low PON1 activity is related to an impaired lipid profile, increasing cardiovascular risk (CVR). The goal of this study was to analyze the effect of common PON1 polymorphisms and...

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PMID: 32556934
DOI: 10.1007/s10067-020-05218-w

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